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Systematic Reviews for Non-Health Sciences

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Formulating a research question

Formulating a question

Formulating a strong research question for a systematic review can be a lengthy process. While you may have an idea about the topic you want to explore, your specific research question is what will drive your review and requires some consideration. 

You will want to conduct preliminary or exploratory searches of the literature as you refine your question. In these searches you will want to:

  • Determine if a systematic review has already been conducted on your topic and if so, how yours might be different, or how you might shift or narrow your anticipated focus
  • Scope the literature to determine if there is enough literature on your topic to conduct a systematic review
  • Identify key concepts and terminology
  • Identify seminal or landmark studies
  • Identify key studies that you can test your research strategy against (more on that later)
  • Begin to identify databases that might be useful to your search question

Systematic review vs. other reviews

Systematic reviews required a narrow and specific research question. The goal of a systematic review is to provide an evidence synthesis of ALL research performed on one particular topic. So, your research question should be clearly answerable from the data you gather from the studies included in your review.

Ask yourself if your question even warrants a systematic review (has it been answered before?). If your question is more broad in scope or you aren't sure if it's been answered, you might look into performing a systematic map or scoping review instead.

Learn more about systematic reviews versus scoping reviews:

Purpose of a framework

Illustration of man holding check mark, woman holding cross, with large page in between themThe first stage in a review is formulating the research question.  A well-formulated question will help:

  • Frame your entire research process
  • Determine the scope of your review
  • Provide a focus for your searches
  • Help you identify key concepts
  • Guide the selection of your papers

There are different frameworks you can use to help structure a question.

Image by jcomp on Freepik

Selecting a framework

The PICO or PECO framework is typically used in clinical and health sciences-related research, but it can also be adapted for other quantitative research.

P — Patient / Problem / Population

I / E — Intervention / Indicator / phenomenon of Interest / Exposure / Event 

C — Comparison / Context / Control

O — Outcome

Example topic: Health impact of hazardous waste exposure

Population Exposure Comparators Outcomes
People living near hazardous waste sites Exposure to hazardous waste All comparators All diseases/health disorders

Fazzo, L., Minichilli, F., Santoro, M., Ceccarini, A., Della Seta, M., Bianchi, F., Comba, P., & Martuzzi, M. (2017). Hazardous waste and health impact: A systematic review of the scientific literature. Environmental Health16(1), 107. https://doi.org/10.1186/s12940-017-0311-8

The SPICE framework is useful for both qualitative and mixed-method research.

S — Setting (where?)

P — Perspective (for whom?)

I — Intervention / Exposure (what?)

C — Comparison (compared with what?)

E — Evaluation (with what result?)

Learn more: Booth, A. (2006). Clear and present questions: Formulating questions for evidence based practice. Library Hi Tech24(3), 355-368. https://doi.org/10.1108/07378830610692127

The SPIDER framework is useful for both qualitative and mixed-method research.

S — Sample

PI — Phenomenon of Interest

D — Design

E — Evaluation

R — Study Type

Learn more: Cooke, A., Smith, D., & Booth, A. (2012). Beyond PICO: The SPIDER tool for qualitative evidence synthesis. Qualitative Health Research, 22(10), 1435-1443. https://doi.org/10.1177/1049732312452938

Click here for an exhaustive list of research question frameworks from University of Maryland Libraries.

You might find that your topic does not always fall into one of the models listed on this page. You can always modify a model to make it work for your topic, and either remove or incorporate additional elements. Be sure to document in your review the established framework that yours is based off and how it has been modified.